Abstract

RHEOLOGY OF BLOOD: BIOPHYSICAL SIGNIFICANCE, MEASUREMENT, PATHOPHYSIOLOGY AND PHARMACOLOGIC THERAPY

*Dr. Manisha Mandal

ABSTRACT

Viscosity is a very important biophysical factor affecting blood flow and normal circulation and an unusual rise in blood viscosity is closely associated with the progression of many chronic diseases, including cerebrovascular and cardiovascular disease, diabetes, polycythemia, vascular dementia, Alzheimer’s, and other disorders. Measurement and improving blood viscosity lead to improvements in diseased conditions and provide direction for therapeutic interventions. Measurement of blood viscosity at different stages of disease during treatment that control it is essential for monitoring the effectiveness of treatments and determining the correlations between hemorheological parameters and other clinical parameters is pertinent to the diagnosis of the disease and to understand the mechanism of action. Thus it is essential to have a better understanding of the fundamental concepts related to the rheology of blood, role of viscosity in physiology, principles of blood viscosity measurement as an important component of patient management, and pathophysiological conditions associated with hemorheological alterations. The purpose of the present communication is to present a review on the facts and phenomenon on the importance of viscosity in disease states, the affecting factors, and the clinical methods of measurement based on the search of electronic database on research papers in SCI and non SCI journals.

Keywords: Hemorheology; Biophysical significance; Alterations; Measurement.