Abstract

BACTERIOTHERAPY EFFECT OF PROBIOTIC IN THE LIPID PROFILE AND PROINFLAMMATORY MARKERS IN OBESE FEMALE.

Fakhri S. Alajeeli*, May. T. Flayyih and Abdul Hadi L. AL Rubaie

ABSTRACT

Obesity is defined as an abnormal or excessive fat accumulation that may impair health. There are inter-individual differences in the amount of excess fat and the distribution of the fat within the body, varying the risk for obesity-associate morbidities. These co morbidities include cardiovascular disease (CVD) and type 2 diabetes (T2D) which along with obesity are the most common, current no communicable diseases. Objective: To determination the role of gut flora in the dislipidimia and immunity markers in obese female patient. Methods: 40 healthy obese female, age between (20-50) years and BMI ≥30 (kg/cm) were participated in this study, there were divided in two groups, group 1(G1) consumed probiotics and group 2 (G2) was consumed placebo for 8 weeks the two group were used same diet with (1200) kcal. the lipid profile, immune markers change was determination. Resutls: The study showed decreasing in the total cholesterol in G1 (12.3%) from (172.7 to (151.33) while in G2 the level of cholesterol was decreased (1.28%) from (158.75) to (156.71) with highly significant difference between two groups. The triglyceride level was decreased about 10.4% in the G1 form (118.59) to (106.25) and increased in G2 placebo group 0.4% from (102.71) to (103.21) with significant difference between two groups. The level of HDL showed significant difference between two groups, the G1 group show increasing 30.67% from (37.55) to (49.07) and G2 showed increased 7.52%. The level of LDL by 29% from (109.29) to (77.5) with significant p<0.01 in the G1 group and the G2 showed decreasing in the level of LDL by 7.52% from (124.24) to (112.9) from (20.85) to (22.42). The level of VLDL in both group but no statistical significant difference. the G1 group showed decreasing in VLDL 10.24% from (23.71) to (21.28) and G2 showed reducing 2.53% from (20.58) to (21.1). the study showed positive correlation with IL-6, TNF α and IL-10. Conclusion: The study showed positive effect of probiotics on the treatment of obesity more study need to determination the role of gut flora in arrangement of body weight.

Keywords: HDL, LDL, VLDL, CVD and T2D.