Abstract

EVALUATON OF ANALGESIC ACTIVITY OF DIFFERENT BRANDS OF DICLOFENAC SODIUM USING TAIL FLICK METHOD

Abhishek Chouhan*, Ankit Karma, Naveen Artani and Dipak Parihar

ABSTRACT

The study involves evaluation of analgesic activity of three different brands (samples) of Diclofenac sodium 50mg tablets consumed in Mandleshwar, Dist. Khargone (M.P.) using tail flick method. The term analgesic is derived from the Greek word Algesia, which means pain. This is an ill defined unpleasant sensation, usually evoked by an external or internal noxious stimulus. Diclofenac sodium is a well known representative of non-steroidal anti-inflammatory drugs (NSAIDs), widely used to control pain and inflammation of rheumatic and non-rheumatic origin. The purpose of this study was to evaluate the analgesic activity of three different brands of Diclofenac sodium tablets purchased from local sources. Diclofenac sodium tablets were assessed according to tail flick methods. Evidence of analgesic activity as indicated by increase in tail flick latency. It suggests that it could possibly have central as well as peripheral action. The findings indicate that the potential use of different brands (samples) of Diclofenac sodium in analgesic dose could produce marked pain relief. The analgesic activity of Diclofenac sodium was observed only at doses (25 mg/kg). Based on the study it may be concluded that different brands of Diclofenac sodium in the dose of 25mg/kg were found to be equally effective in reducing pain in mice.

Keywords: Diclofenac sodium, Algesia.