Abstract

ENHANCEMENT OF DISSOLUTION RATE OF CLASS II DRUG (IRBESARTAN): A SOLID DISPERSION BY USING PLURONIC F108.

Suhas Siddheshwar*, Someshwar Mankar, Sunil Nirmal, Ravindra Laware

ABSTRACT

is poorly water-soluble drug. The objective of the research was to increase the solubility and dissolution rate of drug by formulating a solid dispersion with Pluronic polymer F108 using hot melt method. The dissolution profiles of developed formulations were studied. Drug–polymer interactions were also investigated using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). For the preparation of Irbesartan fast-dissolve tablets, a 1:3 solid dispersion with Pluronic F108 was used with Crospovidone as disintegrants and Microcrystalline cellulose as diluent. Also studied various physical parameters along with drug released. The results showed that a dispersion of the drug in polymer considerably enhanced the dissolution rate. The drug-to-carrier ratio is the controlling factor for dissolution improvement. FTIR spectra show no chemical incompatibility between the drug and Pluronic polymers F108. FTIR and DSC data indicate that Irbesartan was in the amorphous form, which explains the faster dissolution rate of the drug from its solid dispersions. In the optimization study, different analysis showed that an optimum concentration of disintegrants are required for obtaining rapidly dissolving tablets.

Keywords: Irbesartan, Solid Dispersion, Fast dissolving tablets.