Abstract

SOLID LIPID NANOPARTICLES: A NEW APPROACH OF COLLOIDAL DRUG CARRIER

*Parida G. K., Mohapatra S. and Kar R. K.

ABSTRACT

Solid lipid nanoparticles (SLNs) was introduced in the 1991, which is an emerging tools in the field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, Due to their unique size-dependent properties, SLNs offer the possibility to develop new therapeutics and also represents an alternative drug carrier to traditional colloidal systems, such as emulsions, liposome and polymeric micro and nanoparticles, etc. This paper reviews various production techniques for SLNs including their advantages and disadvantages, drug incorporation, loading capacity with the factors affecting drug incorporation and loading capacity and drug release. Different production methods which are suitable for large scale production and appropriate analytical techniques for characterization of solid lipid nanoparticles are discussed in details. Moreover major applications of solid lipid nanoparticles are highlighted. Aspects of solid lipid nanoparticles, route of administration and their bio-distribution are also discussed.

Keywords: Solid lipid nanoparticles, route of administration, colloidal carriers, drug release.