COMPARATIVE STUDY OF EFFICACY OF ACETAMINOPHEN AND IBUPROFEN FOR PAIN CONTROL FOLLOWING ORTHODONTIC SEPARATOR PLACEMENT-A RANDOMISED, DOUBLE CONCEALED CLINICAL TRIAL
Dr. Ganesh P. Chaudhari*, Prof. Dr. G. P. Rauniar, Dr. P. R. Pokharel
ABSTRACT
Pain control after separator placement is one of the most important
aspects of orthodontic treatment as culturally and ethnically distinct
groups interpret and react to pain differently. This is a randomized,
double concealed, 2 parallel arms, longitudinal, multiple doses,
prospective clinical trial study with measurement of pain at the
following time intervals: immediately before separator placement,
immediately after separator placement, 2 hours post-placement, 6
hours post-placement, bedtime and 24 hours post-placement using
visual analogue scales (VAS) during three conditions: teeth not
touching, chewing, and biting back teeth together. In total 36 subjects
were randomly assigned to 1 of 2 experimental groups: 500mg
Acetaminophen or 400 mg Ibuprofen. All treatment groups received an
initial dose to be taken 1hour prior to separator placement and a second
dose to be taken 6 hours after the initial dose. There was statistically
significant decrease in pain level in Ibuprofen group than acetaminophen group (p < .05,
Mann-Whitney U test) for all three conditions over all above mentioned different time
periods except at time just prior to separator placement and 24 hour after separator placement
where it was not significant for any conditions. In each conditions VAS pain score was found to be highest at 24hrs and lowest at 2 hour in either group after separator placement. So it was
concluded that Ibuprofen was found significantly more efficacious than Acetaminophen for
pain control following orthodontic separator placement.
Keywords: Acetaminophen, Ibuprofen, Orthodontic separator pain.
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