Abstract

SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL EVALUATION AND DOCKING STUDIES OF 1, 3, 4-OXADIAZOL HETEROCYCLIC COMPOUNDS CONTAINING DIOXAPHOSPHOL-2- YL-3-PHENYLUREA DERIVATIVES

D. Rajesh*, G. Govindu and L. K. Ravindranath

ABSTRACT

New synthesis, characterization, biological evaluation and docking studies of 1-(5-(4-(5-(4-methyl/trifluoromethyl/nitro)-benzyl) sulfonyl)-1,3,4-oxadiazol-2-yl) methyl)-3-(4-(trifluoromethyl)phenyl)- 3,4-dihydroimidazo[4,5-b] indol-2-yl)-2-oxidobenzo [d] [1,3,2] dioxaphosphol-2-yl)-3-(4-(unsubstituted/ methyl/ methoxy/ fluoro/ trifluoromethyl)phenyl) urea (11a-o) derivatives are described. All the synthesized compounds were characterized by elemental analysis FTIR, 1H-NMR, 13C-NMR, 31P-NMR, and analytical data. All the synthesized compounds were exhibits antibacterial and antifungal activities. Further the docking studies were carried out based on antifungal studies for the model compounds against Glucoamylase Protein and the results found are moderate.

Keywords: 1,3,4-Oxadiazole, antimicrobial, Glucoamylase Protein, docking studies.