Abstract

MICELLES DRUG DELIVERY FOR POORLY SOLUBLE DRUG: A REVIEW

Kaur Kirandeep*, Kaur Jasdeep, Aggarwal Geeta and Kumar Hari S. L.

ABSTRACT

Solubility is one of the important parameters to achieve desired concentration of drug in systemic circulation for achieving required pharmacological response. The poor solubility and low dissolution rate of poorly water soluble drugs in the aqueous gastrointestinal fluids often cause insufficient bioavailability especially for BCS class II and IV. There are various methods to increase the solubility of drug i.e. are chemical changing, utilizing pro-drug approaches. Micelles are colloidal particles with a size usually within a range of 5–100 nm. Micelles consist of amphiphiles or surface-active agents (surfactants), which exist of two distinct regions: mostly a hydrophilic head-group and a hydrophobic tail. There are various factor i.e. solubility and cloud point, CMC, krafft temperature which effect the concentration and temperature on micelles formulation. Surfactant, oil phase and aqueous phase are three main components for micelles formulation. Two mechanisms for drug release from micelle are drug diffusion and micelles dissociation. Micelles formulations are used for various drug delivery including targeted delivery, cancer therapy, ocular delivery, antifungal agent etc.

Keywords: Micelles, Poor solubility drugs, CMC.