Abstract

DESIGN, SYNTHESIS AND IN-VITRO ANTIOXIDANTEVALUATION OF SOME NOVEL -3-{[( 1H-INDOL-4-YL)OXY]METHYL}-6-PHENYL- [1,2,4]TRIAZOLO[3,4-b][1,3,4] THIADIAZOLE DERIVATIVES

Kumara Prasad S. A.*, Srinivasa U., Subrahmanyam E.V.S., Shabaraya A.R.

ABSTRACT

A new series of 3-{[(1H-indol-4-yl)oxy]methyl}-6-phenyl- [1,2,4]triazolo[3,4-b][1,3,4] thiadiazole (5) derivatives are synthesised by the reaction of 2-[(1H-indol-4-yl)oxy] acetohydrazide (2) with Potassium hydroxide and carbon disulfide to form 2-[(1H-indol-4- yloxy) acetyl] hydrazinecarbodithioate (3) which on cyclization with hydrazine hydride and water gave 5-{[(1H-indol-4-yl)oxy]methyl} - 4H-1,2,4-triazole-3-thiol (4) and these triazoles made to react with aromatic acid in dry phosphorous oxy chloride to form the final compounds. Finally, the structures of all the various synthesized compounds were assigned on the basis of IR and 1H NMR spectral data and these compounds were screened for their antioxidant activity.

Keywords: Triazolo thiadiazole, Aromatic acids, Antioxidant activity.