THERAPEUTIC POTENTIAL OF TRIMETAZIDINE ON ANTI – INFLAMMATORY ACTIVITY ON RATS
Puja Kumari*, Vipin Kumar Soni, Vishweshar Bhagat, Vinod Kumar and Jagdish Rathi
ABSTRACT
The present study was designed to elucidate the effects of
Trimetazidine and their administered drug in formalin-induced paw
edema model inflammatory model. Male Lewis rat (divided into 4
groups with 6 animals each) were treated with Group1-control, Group
2-Negative control, Group 3- Diclofenac 50 mg/kg, Group 4-
Trimetazidine 25 mg/kg. On the 28th day, evaluate various behavioral
tests such as Hind paw volume and edema, body weight, arthritis scale
and locomotor activity. Data was analyzed using One way ANOVA
followed by Dunnette‟s test (p<0.05) was considered statistical
significant. Arthritic control group significantly (p< 0.05) impaired
Hind paw volume and edema, body weight and locomotor activity as
compared as compare to negative and therapeutic. Trimetazidine
(25mg/kg; orally) significantly (p< 0.05) reduced hind paw volume and
edema, improved body weight and improved locomotor activity. Further, trimetazidine (25
mg/kg) significantly (p < 0.05) potentiated the anti- inflammatory as compared to their effects
alone. The present study to investigate the trimetazidine has as antioxidant, anti-inflammatory
activity and energy homeostasis hence a could be a promising strategy to treat inflammation.
Keywords: anti-arthritis, locomotors activity, trimetazidine, antioxidant, antiinflammatory.
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