PRELIMINARYSTUDY ON NOOTROPICEFFECT OF VANDA TESSELATA ROOTS
Patel Shivabhai K., Petricia Regina Irene, Dr. N. Venkat Rao, G. Ramu*
ABSTRACT
The research work deals with the screening of ethanolic extract of
Vanda tessellata(AERVT) roots using Elevated plus maze (EPM),
Scopolamine and Diazepam induced models in mice. Piracetam was
used as reference for the study. The Vanda tessellata root is known to
contain saponins, glycosides, alkaloids, steroids and tannins in
phytochemical screening. Since root of Vanda tessellata is used as folk
medicine for diseases of nervous system, we made an attempt to study
for nootropic activity.When this extract is subjected for LD50 studies it
did not produced any abnormal behaviour or mortality even at the dose
level of 2000 mg/Kg body weight in mice. Three different doses100
mg/kg, 200 mg/kg and 400 mg/kg doses were selected for the present
study with respect to maximum dose tested for LD50 study.In this study with the EPM model,
Diazepam and Scopolamine induced amnesic models, the transfer latency is significantly
reduced with 200 mg/kg and 400 mg/kg doses of AERVT. The result of the study confirmed
that the nootropic effect of ethanolic extract was due to several phytoconstituents like
saponins, glycosides, alkaloids which were already reported for their nootropic activity.
Keywords: Vanda tessellataRoxb, Alcoholic extract, Nootropic, Piracetam, EPM, Scopolamine, Diazepam.
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