Abstract

EFFECTIVENESS MIR-93, MIR-20A, MIR-20B, RORC, STAT3, CD4+, SMAD6, SMAD7, MTOR, FOXO1, FOXP3, GATA3, PPARG, INF?, HIF1?, IL-17, IL-23, IL-1R, IL-21R, IL-21, IL-22, IL-6, T-BET, SMAD4, SMAD2, STAT5A, STAT5B, STAT1, STAT4, STAT6, IN CELL DIFFERENTIATION NAÏV

*Shahin Asadi and Elnaz Heydari

ABSTRACT

One of the most basic cells of the immune system in multiple sclerosis patients, th17 cells are involved in many other autoimmune diseases, is effective. miRNAs recently used in the treatment of many diseases. miRNAs, non-coding RNAs with a length of 22-25 nucleotides batch of the regulatory role in various cellular processes. In this study, the use of non-coding miRNAs in Th17 cells in patients with multiple sclerosis to evaluate the performance of these cells was conducted.

Keywords: multiple sclerosis, cells, Th17, miRNAs, CD4 + gene RORC, gene STAT3, autoimmune disease.