WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

  • WJPPS: APRIL ISSUE PUBLISHED
  • April Issue has been successfully launched on 1 April 2024.

Abstract

ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF NOVEL DEHYDRO PEPTIDES

Sravanthi Chirra* and Venkateshwar Rao Jupally

ABSTRACT

Peptides and its derivatives demonstrate a diverse array of biological activities. A series of N-2-(benzoylamino)-3-(substituted phenyl-1-oxo-2-propenyl) dehydro serines (C1-10) / dehydro threonines (D1-10) were synthesized by stirring of dipeptides of serine and threonines with mesyl chloride in methylene chloride in the presence of triethylamine. The chemical stuctures of synthesized compounds were characterized by IR, 1HNMR. All the compounds screened for anti inflammatory and antioxidant activities. Among all 4-isopropyl derivatives A7, B7 have shown significant excellent anti inflammatory activity. In dehydro serines syringaldehyde derivative (A8) showed highest NO scavenging activity. In dehydro threonines 4-methyl derivative (B5) showed significant activity in scavenging of nitric oxide.

Keywords: Dehydro peptides, Dehydroamino serines/Threonines, Anti Inflammatory Activity, Antioxidant activity.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More