Abstract

VITAMIN D STATUS IN CHRONIC KIDNEY DISEASE: AN OBSERVATIONAL STUDY

Dr. Chaitali Bajait*, Dr. Ganesh Dakhale, Dr. Sonali Pimpalkhute, Dr. Yogesh Tathod, Dr. Latesh Raghute

ABSTRACT

Background: Chronic kidney disease (CKD) is an emerging public health problem. Though hypovitaminosis D is common in CKD but it goes undetected because of cost of the investigation. In view of the association of hypovitaminosis D with disease and its implications, the present study was planned with a objective of estimating serum 25(OH)D3 level in patients of CKD and comparing it with non-CKD patients. Material and Method: In the present observational study , 25(OH)D3 level was estimated in blood samples of 18 CKD patients and compared it with vitamin D3level of non-CKD patients after obtaining approval from institutional ethics committee. Results:All subjects regardless of renal status had hypovitaminosis D (< 30ng/mL) There was significant difference in mean serum vitamin D3 level among CKD and non-CKD patients. Mean Vitamin D3 level was significantly low and also less than normal range in CKD patients though 13 patients with CKD were on supplementation of active vitamin D3. In CKD group, there was no difference in vitamin D3 level among those who were taking active vitamin D3 and those who were not on vitamin D3 supplementation. Conclusion: CKD group had severe degree of vitamin D deficiency which were not improved with vitamin D3 supplementation. However because of small sample size, it is difficult to come to any conclusion. So further studies should be conducted to identify predictive variables that could be used for prognostic guidance in CKD patients.

Keywords: Cholecalciferol, Chronic kidney disease, HPLC.