Abstract

DRUG USE EVALUATION OF PROTON PUMP INHIBITORS IN A PRIVATE TERTIARY CARE TEACHING HOSPITAL

*Rajendra Singh Airee, Aastha Rawal, Nimmy N. John and Binu KM

ABSTRACT

Proton Pump Inhibitors are among the most common classes of medications prescribed for gastric acid suppression. Though they were previously thought of as safe, recent literature has shown risk associated with their use including increased risk for Clostridium difficile infection, Pneumonia and fractures. The objective of this study was to assess utilization pattern of PPIs and to evaluate for its rational use. A prospective observational study was carried out for a period of three months, 100 patients were selected from various inpatients departments who were prescribed with PPIs, excluding emergency ward and data were collected using standard data entry format. Defined route of administration, convenience of the indication for PPIs use were considered. In the study population Male were found more (56 %,) than the female (44%). Most of the PPIs were prescribed for Male with a mean age group of 50-60years (26%). GIT related disorder were most prominent diagnosis found in 21% patients. Of total prescription, the major prescription was for Pantoprazole (74%) and in 50% of the prescription PPIs was given by oral route and in remaining by parenteral route and combination of both oral and parenteral. The most prescribed brand was APAN-40(PANTOPRAZOLE) in 29 prescriptions and 61 % of patients were prescribed with PPIs along with NSAID/Antibiotics. The major drug interaction was found with the use of PPIs along with Clopidogrel, whereas with other drugs studied interaction was moderate. The study found use of PPIs in wide range of indications. Drug usage in some unrelated disorders was common. This study may be useful for physicians to reduce PPIs prescriptions in inpatients with no apparent indications.

Keywords: Proton Pump Inhibitors (PPIs), Prospective, Gastrointestinal Tract (GIT).