Abstract

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF AN ANTI-DIABETIC DRUG OF GLIBENCLAMIDE

Dr. S. J. Shankar*, Palak P. Kapadiya, Makaranda Prabhu, Prarthan B. Raju

ABSTRACT

The aim of the present investigation was to prepare Glibenclamide transdermal patches and to study the influence of various polymer combination and polymer ratios on physiochemical parameters includes in-vitro drug release profile. Glibenclamide matrix type transdermal patches were prepared using polyvinyl alcohol (PVA), Hydroxy propyl methyl cellulose (HPMC), Eudragit RL-100 in different ratios. Di-butyl phthalate was used as a plasticizer and dimethyl sulfoxide used as a permeation enhancers which were added by solvent casting method. The systems were evaluated for various parameters like Thickness, Weight variation, Folding endurance, Moisture absorption, Moisture loss, Drug content, Drug permeation, Drug–polymer interactions. In- vitro drug release studies and Ex-vivo studies were performed by using Franz diffusion cells. Variations in drug release profile were observed among various formulations. The drug–polymer interaction results suggested no interaction between drug and polymers was observed. From all the formulations, formulation F10 was selected as the best formulation and was stable for period of up to 90 days. Glibenclamide (M.W. 494.004 g/mol) is a potent oral sulfonylurea hypoglycemic agent. It is currently available for treating hyperglycemia in Non-insulin dependent Diabetes Mellitus (NIDDM-type 2). Plasma half-life is 4-6hrs; which make frequent dosing necessary to maintain therapeutic blood level of the drug for a long term treatment. Therefore controlled released Transdermal preparation of Glibenclamide was prepare to give sustain effects as compared to conventional multiple oral dosing.

Keywords: Transdermal drug delivery; Matrix controlled Patch; Glibenclamide; HPMC; Eudragit RL100; Ex-vivo skin permeation studies.