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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

COMPARATIVE ANALYSIS OF HEPATOPROTECTIVE EFFECT OF ETHANOL EXTRACTS OF GONGRONEMA LATIFOLIUM AND ALTERNANTHERA DENTATE LEAVES IN RATS.

Sylvester Chika Ohadoma*

ABSTRACT

Objective: To comparatively investigate the hepatoprotective effect of ethanol extracts of Gongronema latifolium and Alternanthera dentate leaves in experimental rats. Methods: Two sets (A and B) of four groups comprising five rats each were used. Each of A and B sets had a control group while the other 3 groups were administered different concentrations 100, 200 and 300 mg/kg of ethanol extracts of G. latifolium and A. dentate respectively, once daily for 14 days. The alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total protein (TP), albumin (ALB) and bilirubin (BIL) levels were evaluated. Results: All medicaments significantly (p<0.05) showed reduced ALT, AST, ALP, ALB, BIL and increased TP levels, with G. latifolium exhibiting greater efficacy than A. dentate. Conclusion: The leaves extracts of G. latifolium and A. dentate possess hepatoprotective effect.

Keywords: Gongronema latifolium, Alternanthera dentate, hepatoprotective effect, comparative analysis.

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