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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

BIOLOGICAL ACTIVITIES OF CRUDE EXTRACTS FROM PENICILLIUM WAKSMANII ISOLATED FROM MOSQUITOES VECTORS OF TROPICAL DISEASES

Jacqueline Santos Cruz,*, Gisela Lara da Costa and José Daniel Figueroa Villar

ABSTRACT

Considering that Penicillium genus are capable to produce a diversity of secondary metabolites, this work describes the production of bioactive metabolites from Penicillium waksmanii Zalessky, using fifteen strains isolated from mosquitoes vectors of tropical diseases. Strains were fermented in malt extract for seven days and extracted with ethyl acetate. All extracts were tested against bacteria and yeast, being active for at least one microorganisms used. Chemical and biological investigation on the ethyl acetate extract of this strain resulted in the isolation of two compounds identified by NRM technique: citrinin and 2-(4-butyl-phenyl)-ethanol.

Keywords: Penicillium waksmanii, biological activity, secondary metabolites, mosquitoes.

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