Abstract

FORMULATION AND EVALUATION OF INTRA GASTRIC FLOATING RETENTIVE DRUG DELIVERY SYSTEM OF TERBUTALINE SULFATE

Pankaj Sharma*, Shivani Kala and Divya Juyal

ABSTRACT

The present study deals with the formulation and evaluation of Terbutaline loaded Intra Gastric floating drug delivery The floating tablets were prepared by direct compression method because of its cost effectiveness and due to reduce number of manufacturing steps. The tablets were formulated using hydrophilic polymers HPC, HPMC K15M and HPMCK100M along with an effervescing agent sodium bicarbonate. The in-vitro buoyancy of IGF tablets was induced by sodium bicarbonate without compromising the matrix integrity with the possible shortest bouncy lag time of 10.33 sec and buoyancy duration of up to 24 h. The in-vitro dissolution profiles of all the formulations of Terbutaline sulphate were controlled over a period of 12 hours. Optimized formulation F9 containing 50 mg HPMCK100M, 18 mg MCC, and 30 mg sodium bicarbonate was consider as the best Formulation with respect to sustained in-vitro drug release for 12 hours The best fit with the highest determination R2 coefficients was shown by Higuchi model (which indicates drug diffusion) The developed formulation was found to be stable during the stability studies of three month indicating good stability of the tablets.

Keywords: HPMCK100M, HPC, HPMC K15M, Terbutaline, Gastro retentive.