Abstract

DENOSUMAB-A NEW THERAPEUTIC OPTION FOR OSTEOPOROSIS

*Dr. Sapna Patil

ABSTRACT

Osteoporosis is a multifactorial progressive skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, predisposing it to increased fracture risk.[1] The capacity of bone to resist mechanical forces and fractures depends not only on the quantity of bone tissue but also on its quality.[2] Osteoporosis is called a "silent disease" because it progresses without symptoms until a fracture occurs. Because of larger skeletons and no period of rapid hormonal change osteoporosis progresses more slowly in men than in women.[3] The fractures caused by osteoporosis have a great impact on public health, as they are often associated with increased morbidity, mortality and high economic cost. Thus, in the last two decades pharmacological and non-pharmacological treatment (usually based on physical exercise) options have been largely developed to reduce the risk of fractures in osteoporotic patients.

Keywords: .