Abstract

PHYTOCHEMICAL EVALUATION AND PHARMACOLOGICAL SCREENING OF ETHANOLIC BARK EXTRACT OF DOLICHONDRONE FALCATA FOR ANTIHYPERLIPIDEMIC ACTIVITY IN ALLOXAN- INDUCED DIABETIC ALBINO WISTAR RATS

Mehnoor Farheen* and Chakrapani Ramesh

ABSTRACT

The present study was aimed to elucidate antihyperlipidemic effect of ethanolic extract of bark of Dolichondrone falcata Bignoniaceae family by alloxan-induced hyperlipidemia in albino wistar rats and to investigate the serum lipid levels. Hyperlipidemia was induced experimentally in rats by inducing alloxan at a dose of 150mg/kg body weight. Hyperlipidemic rats were administered fresh ethanolic root extract at the dose of 200mg/kg b.w and 300mg/kg b.w and the standard drug Atorvastatin 10mg/kg b.w. Blood samples were collected after 24hrs of last administration and used for estimation of lipid profile. Serum cholesterol levels were estimated using standard methods. Fresh ethanolic extract at a dose of 200mg/kg b.w and 300mg/kg b.w resulted in dose dependent significant decline in total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein-cholesterol (VLDL-C). Further, in comparison to atorvastatin 10mg/kg resulted in comparable decrease of total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein-cholesterol (VLDL-C) levels. The phytochemical analysis revealed the presence of flavonoids, triterpenoids, alkaloids, phenolic compounds, tannins and saponins. The results of present study revealed antihyperlipidemic effect of Dolichondrone falcata in alloxan induced rats.

Keywords: Dolichondrone falcata, Hyperlipidemia, Atorvastatin.