Abstract

DNA SEQUENCING TO TRACE DRUG RESISTANCE - AN OVERVIEW

Hariprasath Kothandam (PhD)*, Judith John (Pharm D) and Jeswin Jacob (Pharm D)

ABSTRACT

Drug resistance is the reduction in efficacy of a drug such as an antimicrobial, anthelmintic and antineoplastic in curing a disease or condition. The various causes for antimicrobial drug resistance includes selective pressure, mutation, gene transfer, societal pressures, inappropriate drug use, inadequate diagnostics, hospital use and agricultural use of drugs. The diagnosis of drug resistance has been performed by lab tests that challenge the isolated microbes to grow and survive in the presence of the drug. In this review we discussed about some DNA sequencing methods to identify drug resistance.

Keywords: Drug resistance, antimicrobial, anthelmintic, antineoplastic and DNA sequencing test.