Abstract

HEPATOPROTECTIVE AND CARDIOPROTECTIVE EFFECTS OF MOMORDICA CHARANTIA, GYMENMA SYLVESTRE AND WITHANIA SOMNIFERA IN ANIMAL MODEL OF DIABETES MELLITUS

Sadia Saleem Rao* and Rahila Najam

ABSTRACT

Diabetes mellitus has been highlighted as a major health concern in the recent years. It is frequently associated with cardiovascular diseases and liver damage. The present study explored the effect of traditional anti-diabetic herbal product on hepatic and cardiovascular system. Study was conducted on alloxan induced diabetic rats. Glibenclamide was taken as standard drug in this research study. The results revealed that anti-diabetic herbal combination showed significant decrease in CPK, SGPT, SGOT and γ-GT levels (p<0.001) in comparison to diabetic control. Level of alkaline phosphatase was insignificantly increased by herbal drug in comparison to diabetic control. Moreover, herbal drug combination showed better result than standard in controlling the levels of SGPT and γ-GT (p<0.001). However, results showed insignificant differences in SGOT and ALK levels between herbal drug combination group and standard group. Furthermore, herbal drug combination did not show better effect than standard in controlling levels of CPK. We can conclude that herbal drug combination could be a potential combination drug in managing hepatic and cardiovascular complications of diabetes mellitus.

Keywords: Diabetes, momordica charantia, gymenma sylvestre, withania somnifera.