IN VITRO ANTI-INFLAMMATORY ACTIVITY OF SOME COMMON FRUITS OF WEST COAST OF INDIA.
Srividya* and Chandra M.
ABSTRACT
The objective of the study is to evaluate Anti-inflammatory activity of different fruits viz Annona reticulata, Vitis vinifera, Punica granatum, Malus domestica, Citrus sinensis, Ananas comosus, Carica papaya, Manilkara zapota, Citrullus lanatus and Musa cavendishii. Anti-inflammatory activity was evaluated using Albumin denaturation assay and Proteinase inhibitory activity at different concentrations. Diclofenac sodium was used as a reference drugs for the study of Anti- inflammatory activity. Among ten common fruits, Vitis vinifera showed highest inhibition in both Albumin denaturation assay and Proteinase inhibitory activity with IC50 values 114.03μg/ml and
120.69μg/ml respectively. Fruit extract of Musa cavendishii showed lowest inhibition with IC50 values 360.88μg/ml and 367.37μg/ml for Albumin denaturation and Proteinase inhibitory activity respectively. In Albumin denaturation and Proteinase inhibition activity assay, Diclofenac sodium showed highest inhibition with IC50 values 67.44μg/ml and 70.95μg/ml respectively.
Keywords: Albumin denaturation, Anti-inflammatory activity, Diclofenac sodium, Proteinase inhibition.
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