Abstract

SOLUBILITY ENHANCEMENT STUDIES OF SOLID DISPERSION

Anju Kumari*, Dr. Sunil Kumar Prajapati, Pragya Niranjan

ABSTRACT

The solubility behavior of drugs remains one of the most challenging aspects in formulation development. With the advent of combinatorial chemistry and high throughput screening, the number of poorly water soluble compounds has dramatically increased. Although solid solutions have tremendous potential for improving drug solubility. Solid dispersion technologies are particularly promising for improving the oral absorption and bioavailability of BCS Class II drugs. The focus of this review article is on the advantages, limitations, various methods of preparation and characterization of the solid dispersion. The different types of solid dispersions based on their molecular arrangement have been highlighted.

Keywords: Solid solution, Solubility, Solid dispersion, Bioavailability.