Abstract

IN VITRO ANTI-DIABETIC ACTIVITY OF MUNTINGIA CALABURA ROOT PROTEINS

Mohamed Azmathulla Khan Y, Dinesha Ramadas*, Subhas Chandrappa Mundasada, Santosh Kumar N, Harsha R Kashyap, Chikkanna D.

ABSTRACT

To investigate the in vitro Antidiabetic activity of proteins from Muntingia Calabura root. Phytochemicals of Muntingia Calabura root proteins was analyzed by using standard methods. In vitro antioxidant studies were carried out for the Muntingia Calabura root proteins using DPPH model, In vitro anti-diabetic studies was done by alpha amylase enzyme, alpha glucosidases enzyme inhibition studies and Glucose uptake in Yeast cells studies. The phytochemical screening of Muntingia Calabura root proteins revealed that the extract rich in proteins and contains negligible amount of sugars and polyphenols. The in vitro antidiabetic potential of extract was confirmed through alpha amylase enzyme, alpha glucosidases enzyme inhibition studies and Glucose uptake in Yeast cells studies. The results of the present study concluded that the Muntingia Calabura root proteins possess significant antioxidant and antidiabetic activity. The potential pharmacological activity of Muntingia Calabura root proteins might be due to the presence of proteins.

Keywords: Muntingia Calabura antioxidant, phytochemicals, anti-diabetic.