Abstract

FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERE OF CAPTOPRIL

Neha Usrete*, Ashwani Mishra, Anupam Pathak

ABSTRACT

Microsphere is one of the multiple unit dosage forms. In recent years, in order to get better absorption and bioavailability in patients, the use of multiple unit dosage form which are dispersed in gastrointestinal system more homogeneously than the single unit dosage form like tablets have become more common. Drug Captopril is the ideal candidate for Gastroretentive mucoadhesive formulation because of its short half life, stability in to the gastric pH. Gastroretentive mucoadhesive formulation of Captopril was developed by solvent evaporation method using various concentration of Carbopol-934 and Hydroxyl propyl methyl cellulose in combination and they were evaluated for production yield, Particle size determination, Surface morphology, Percent drug entrapment efficiency, Swelling index, In- vitro drug release study, In- vitro mucoadhesion study and Interaction study by Differential Scanning calorimetry. After analyzing different evaluation parameters including drug release kinetics and mucoadhesion, formulation F-6 having (Carbopol: HPMC) 2%, Dispersed to continuous phase ratio 1:6 was selected as best formulation for delivery of captopril as a gastroretentive mucoadhesive microspheres.

Keywords: Gastroretentive mucoadhesive, mucoadhesion, Carbopol: HPMC.