Abstract

FORMULATION AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLETS OF CEFIXIME TRIHYDRATE

Prabhjot Singh*, Neha Srivastav and Amit kapoor

ABSTRACT

The objective of the present investigation was to formulate and evaluate gastro retentive floating tablets of cefixime trihydrate. A novel gastro retentive drug delivery system of cefixime trihydrate was formulated in an effort to increase gastric residence time and thereby increase drug bioavailability. Rapid gastro intestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. Nine formulations of floating tablets were prepared using direct compression method containing 200 mg of cefixime trihydrate and various polymers like hydroxypropyl methylcellulose (HPMC K 100M), xanthan gum and fenugreek mucilage in varying proportions. Micro crystalline cellulose was used as swelling agent and buoyancy was achieved by adding fixed amount of an effervescent agent sodium bicarbonate. All the formulations were evaluated for physicochemical properties, in vitro buoyancy and in vitro drug release. Floating lag time observed for all the tablets was less than 1 minute and the duration of floating was greater than 12 hrs. Formulation F5 containing equal ratio of xanthan gum and fenugreek mucilage (25mg) showed optimum in vitro drug release of 83.53% at the end of 12 hrs.

Keywords: Gastro retentive floating tablets, Cefixime trihydrate, Fenugreek mucilage, Xanthan gum, Buoyancy, In vitro release.