Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL ISATIN DERIVATIVES

H. Ramana*, R.Vasanthi and Ch.Pavan Kumar

ABSTRACT

Isatins and its derivatives are useful for the synthesis of several chemical and pharmacological classes of therapeutic agents. Therefore, in the present investigation it has been considered worthwhile to synthesize some new Isatins derivatives by conventional methods. The chemical structures of the synthesized compounds were confirmed by using spectral and elemental analysis methods. Screening for their Antimicrobial, In-vitro anti-helmenthic and In-vitro anti-inflammatory activities. All the novel Isatin derivatives exhibited mild to moderate activity. Compounds 3, 4, 9 & 12 exhibited better activity than the other test compounds.

Keywords: Isatin anti-helmenthic, anti-inflammatory, In-vitro.