Abstract

STUDY OF RELATIONSHIP BETWEEN ANTIDEPRESSANTS INTERACTION AND TOXICITY AMONG PATIENTS: A CASE STUDY

Dr. Seyed Sam Banisadr*, Dr. Padmaja K, Dr. Mahesh M. Nosenoor, Dr. Sumi Jose

ABSTRACT

This study aims at examining the relationship between antidepressants interaction and toxicity among patient with antidepressant interaction. The essential information was collected in a year from the information in the health records of 108 patients admitted to Imam Khomeini Hospital due to the interaction of antidepressants caused toxicity. The existing drug interactions and their severity, according to Hansten & Horn’s classification, were categorized in three groups: severe, moderate and mild drug interaction. The results indicated that there is a significant relationship between drug items and toxicity level caused by drug interaction, and with the increasing number of used drugs, patients are more likely to have severe toxicity. In addition to this, the maximum drug interaction was found among patients who used two different types of antidepressants (more than 60%), as the maximum interaction was observed among antidepressants groups of two drugs Tricyclic Antidepressant (TCA) & Selective Serotonin Reuptake Inhibitor (SSRI) (more than 32%), which had a significant relationship with severe toxicity among patients. finally, there was no significant relationship between gender and toxicity caused by drug interaction.

Keywords: Drug, interaction, antidepressants, toxicity, gender, Tricyclic Antidepressant, TCA, Selective Serotonin Reuptake Inhibitor, SSRI.