Abstract

FORMULATION AND INVITRO-EVALUATION OF GASTRO-RETENTIVE SUPERPOROUS HYDROGEL TABLETS

P. Sushma*, P. Vishnu, A. Prathyusha, V. Uma Maheshwar Rao

ABSTRACT

Superporous hyrogel(SPH) is 3 dimensional network of hydrophilic polymer that are not soluble and absorb large amount of water in short period due to it contain numerous inter connected microscopic pores. These systems swell rapidly and maintain integrity in the harsh stomach environment. Because of porous structure SPHs posses more surface area and shorter diffusion distance. Due to this they swell very rapidly on contact with water. Superporous hydrogel does not have only fast swelling but also have properties like slipperiness, biodegradability, biocompatibility, high mechanical strength, high swelling capacity and stability in acidic condition of stomach. Swollen hydrogel strong enough to withstand with shear force, abrasion, pressure generated in stomach by gastric fluid. Because of this property these devices are proposed for extending gastric residence time of drug. To overcome the problems associated with convetional superporous hydrogels related to mechanical strength modified by developing second generation of superporous hydrogel composite (SPHCs) and third generation of superporous hydrogel hybrids (SPHHs). This review includes various generations, methods of preparation, techniques of drug loading, method for synthesis of superporous hydrogels, list of various reagent used in synthesis of superporous hydrogel and their role, applications, evaluation of superporous hydrogel.

Keywords: Polymers, Crosslinkers, Superporous hyrogels, Mechanical strength and Swelling property.