STABILITY-INDICATING RP-HPLC METHOD DEVELOPMENT FOR THE ESTIMATION OF PANTOPRAZOLE SODIUM IN TABLET DOSAGE FORM
Faraat Ali*, Dr. G. N. Singh, Dr. P. L. Sahu, Anuj Prakash, Manisha Trivedi, Tanzeel A. Khan
ABSTRACT
The aim of the present study is to develop a simple, sensitive, rapid, accurate and precise reverse phase high performance liquid chromatographic (RP-HPLC) method for the estimation of Pantoprazole sodium in bulk and pharmaceutical dosage forms. Analytical method was developed by using Waters X-Bridge Shield C-18 (4.6×150 mm, 5μm) column; mobile phase consisting of ACN and ammonium bicarbonate phosphate buffer at pH 9.0; the flow rate of 1.0 ml/min and detection wavelength 214nm and eluted at 4.766 min. The method was found to be simple, accurate, economical, Precise and reproducible. There was no interference of any degradants and excipient in the determination of drugs in marketed formulation. So the method can be successfully applied for routine analysis.
Keywords: Pantoprazole, Acetonitrile, HPLC, Development.
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