Abstract

COMPARISON OF EVALUATION PARAMETERS OF TWO DIFFERENT BRANDS OF PARACETAMOL TABLETS.

Poonam Verma*, Shivpratap Bhadouria, Sanjit Pramanik, Nisha Yadav

ABSTRACT

Paracetamol tablets are popular OTC products among patients marketed by a lot of suppliers around the world, being extensively used as antipyretic and general analgesic. The purpose of this research work was to compare and evaluate quality standards in the various brands of paracetamol tablets. Two different brands of paracetamol 500mg manufactured by local companies were randomly sampled from different Pharmacy shops. Evaluations of parameters were performed through the determination of weight variation, hardness, friability, and disintegration time using standards techniques .the values were compared with the standards. Results: Wide variations in the parameters were seen in the tablet formulation manufactured by the two different local companies. (Brand A) were comparable with standards. Conclusion: The manufacturing standards are not strictly followed by some local companies and there is need for proper monitoring.

Keywords: Paracetamol, Hardness, Friability, Disintegration Time.