Abstract

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ALOE VERA IN DRUG INDUCED HEPATITIS

Dr. Shaily Bhatt*, Dr. Harshvardhan Kumar, Dr. Monica Sharma, Dr. K.K. Saxena, Dr. Gaurav Garg and Dr. Ganesh Singh

ABSTRACT

Drug-induced liver injury (DILI) is an emerging problem, and has been a long-standing concern in the treatment of various disease states. The liver has a central role in drug metabolism and detoxification, and is thus vulnerable to injury. Liver plays a vital role in elimination and metabolism of chemicals but some medicinal agents can damage the organ if given in therapeutic or high dose. Aloe Vera is one of the most popular plants in the world, and is has been used frequently in history for its medicinal properties. Material &Methods: A total of 30 male and female patients of age group between 15- 65 years, diagnosed clinically and biochemically as the case of drug induced hepatitis and ready to give consent were recruited in the study from SVBP Hospital, LLRM Medical College Meerut (U.P), 250004. Subjects who fulfilled selection criteria were randomized into two groups. Fifteen patients belonging to control group received conventional treatment for drug induced hepatitis while fifteen patients enrolled in treated group were given conventional treatment for drug induced hepatitis supplemented with Aloe vera juice (Patanjali Ayurved ltd, Haridwar) in dose of 20 ml BD orally. Every patient was followed up for 6 weeks. Serum bilirubin, serum Alanine transaminase (ALT), serum levels were measured initially and at the end of 2, 4 and 6 weeks. Results, Interpretation & Conclusions: Intragroup comparison using Wilcoxon rank sum test demonstrated a statistically significant (p<0.05) decrease in above mentioned parameters for both treated and control groups at all intervals of time. Intergroup comparison done by kruskal wallis test, revealed statistically significant (p<0.05) difference in both of the mentioned parameters between treated and control groups at all intervals of times.

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