Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF COPPER (II) COMPLEX WITH CIPROFLOXACIN ANTIBIOTIC.

Richa Kothari, Brajraj Sharma*, Swati Sahawal, Kumari Neha, Sunanda Kr. Mandal, Shruti Birthare and Vipul Shivhare

ABSTRACT

New complex of copper (II) with ciprofloxacin & thiosemicarbazide Schiff base has been synthesized, Schiff base ligand and its Cu(II) complex were characterized by various physico -chemical techniques like elemental analysis, m.pt. , TLC, molar conductance measurement, magnetic susceptibility measurement, LC-MS, H1NMR, FT-IR and electronic spectral studies. The magnetic moment and electronic spectra studies suggested distorted octahedral geometry for Cu (II) complex. The monoanionic thiosemicarbazonate ligand act in a tridentate mode, binding through azo-methine nitrogen and sulfur atom. The synthesized ligand and its Cu (II) complex were screened for their invitro antibacterial activity using disc diffusion method against the gram positive and gram negative bacterial strain E. coli and S. aureus using nutrient agar medium. Streptomycin was used as standard in the test. Both the compounds showed remarkable antibacterial activity in comparison to antibiotics. Antioxidant activity of the ligand and its Cu (II) complex was screened using the DPPH scavenging assay. Both the compounds showed potent antioxidant activity in the range 80 – 97%.

Keywords: Ciprofloxacin, thiosemicarbazide, spectral studies, antibacterial activity, copper chloride, anti oxidant activity.