Abstract

MESOPOROUS SILICA NANOPARTICLES FOR CONTROLLED DRUG DELIVERY

Surabhi Rashi*, Dr. S.K. Prajapati and Devender Singh

ABSTRACT

Nanotechnology is a fast growing area, involving the fabrication and use of nano-sized materials and devices. Various nanocomposite materials play a number of important roles in modern science and technology including pharmaceutical science, among these materials mesoporous materials covers large number of applications in drug delivery system. Mesoporous materials emerged as a promising candidate that can deliver a variety of drug molecules in a controllable and sustainable manner. In particular, mesoporous silica nanoparticles are widely used as a delivery reagent, sol-gel derived mesoporous silica nanoparticles in soft conditions are of main interest due to simplicity in production and modification and the capacity to maintain function of bioactive agents. The properties of mesopores, including pore size and porosity as well as the surface properties, can be altered depending on additives used to fabricate mesoporous silica nanoparticles. This review aims to present the state of knowledge of currently available drug delivery system and identify properties of an ideal drug carrier for specific application, focusing on mesoporous silica nanoparticles.

Keywords: Mesoporous silica nanoparticle, targeted drug delivery, controlled release, sol-gel process, properties.