Abstract

THE EFFECT OF LONG TERM ADMINISTRATION OF METFORMIN ON PROLACTIN LEVEL AND C-REACTIVE PROTEIN IN NEWLY DIAGNOSED WOMEN WITH TYPE II DIABETES MELLITUS

Ban Hoshi Khalaf*

ABSTRACT

Introduction: The role of hypothalamus and neurohormonal circuitry in glycemic control that incorporates the cross talk between blood born factors and neurons is considered an important mechanism involved in diabetes pathophysiology. The theory emphasizes that the circadian neuroendocrine rhythm (Dopamine, 5-HT and norepinephrine) in the hypothalamus is altered in diabetes mellitus. Many experimental studies indicate an influence of prolactin on type 2 diabetes mellitus. This study aims to investigate the effect of different doses of metformin on prolactin and C-reactive protein in newly diagnosed female with diabetes mellitus. Material and methods: 60 newly diagnosed type 2 diabetic patients were divided into three groups according to the dose of metformin in addition to 20 diabetic free (control group). All patients were treated with metformin for 6 months. Result: Treatment with different doses of metformin result in a significant reduction in prolactin and C-reactive protein levels. Our data indicate that metformin significantly decreases prolactin level possibility via increasing the dopamine tone and attenuating the pro-inflammatory response via reduction in CRP. This can have an important role in improving the insulin resistance and other outcome of diabetes. Further investigations required to determine the exact role of prolactin in diabetes.

Keywords: Type II diabetes mellitus, prolactin, C-reactive protein, metformin.