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Abstract

SYNTHESIS, ANALGESIC AND ANTIEPLIEPTIC PROPERTIES OF SOME NOVEL N-SUBSTITUTED SUCCINIMIDE

Omran N. R. Fhid*., Talal H. Zeglam, Shaban E. A. Saad., Mohammed. Sh. Shlaka., Mohammed.A. Dao

ABSTRACT

The present study was aimed to study the analgesic and antiepileptic potency of some New succinimide derivatives. Various aromatic amines clubbed succinimide derivative compounds 2-13 were synthesized by using succinic anhydride and various amines in reflux synthesizer. The structures of the synthesized derivatives were confirmed by means of physical and spectral analysis. All the synthesized compounds were evaluated in vivo for analgesic and antiepileptic activities by using standard experimental models. The results indicated that most of them were found to exhibit good activity.

Keywords: Succinimide, Analgesic activity, anticonvulsant activity, reflux synthesizer.


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