Abstract

EFFECT OF ANTIBIOTICS ON MODELLED NOVEL OUTER MEMBRANE PROTEINS OF EDWARDSIELLA TARDA- A FISH PATHOGEN

Damayanthi Devi*

ABSTRACT

Edwardsiellosis is a fish disease caused by Edwardsiella tarda, is one of the major damages to the aqua farming. It infects a host of fishes and manifests several diseases like systemic hemorrhagic septicemia, ulcers, necrosis to liver, kidney, and spleen along with emphysemous putrefactive diseases. Not only in fishes, but these bacterial incidences also noticed in snakes and humans as well. The present study deals with the preventive step which could be considered for protecting the aquaculture. A novel outer membrane protein acts as a drug target for the present investigation. The modeled outer membrane protein was docked with the selected antibiotics to evaluate the potential drug. It was noted that the antibiotic doxycycline was found to be -15.8219 with nine hydrogen bond interactions and identifying itself as the potential drug for Edwardsiellosis. The results were very promising and showed be an excellent alternative for the aquaculture protection.

Keywords: Edwardsiellosis, Edwardsiella tarda, outer membrane protein, MOE, aquaculture.