Abstract

EVALUATION OF SOLANUM SURATTENS LINN. MUCILAGE AS TABLET BINDER

Bhabani Shankar Nayak*, P. Ellaiah, Suprava Sethy, Suraj Sahoo, Bikash Kumar Sarangi

ABSTRACT

The Solanum Surattens Linn fruits, family, Solanaceae, is traditionally eat by local Tribes. The fruit mucilage is used as gum for pasting sheets of paper and card board. The present study is an attempt to investigate the efficacy of S. Surattens fruit mucilage as tablet binder. The mucilage was extracted with ethanol, screened phytochemically for detection of mucilage and physiochemical characteristics of mucilage were studied. The heavy metal study in soil, study of toxicity, gum-experimental tablet excipient interactions using Fourier Transform Infrared Spectroscopy and Differential Scanning Colorimetry ensured its safe use as a tablet binder. Tablets were manufactured using Diclofenac sodium and granules were prepared by wet granulation method with different concentration (4, 6, 8, 10 and 12% w/v) of mucilage as tablet binding agent. The prepared granules were evaluated for percentage of fines and flow properties. A comparison was made against the tablets prepared with 5% w/v starch paste as standard binder, based on studying the standard parameters like hardness, thickness, friability, weight variation, disintegration time and in vitro dissolution. The tablets had good tablet physiochemical properties and the drug release was more than 90% within 1.5 h. S. Surattens at 8% w/v was found to be effective as tablet binder. All the formulations were subjected to stability studies and showed stable with respect to tablet parameters. Thus this gum will be a non-toxic, bio- degradable, economic and easily available option as tablet binder in the list of pharmaceutical excipients.

Keywords: S. Surattens, mucilage, tablet binder, hardness, pharmaceutical excipient.