Abstract

PYRAZINAMIDE INDUCED MULTIPLE ADVERSE DRUG REACTIONS: A CASE REPORT

Yasaswini B, Apollo James*, Sudhakar. R, Minu K George, T. R. Ashok Kumar, T. Sivakumar

ABSTRACT

Tuberculosis (TB) is a global pandemic and affects one third of the world’s population. Drug-induced Liver Injury (DILI) is a problem of increasing significance, but has been a long-standing concern in the treatment of Tuberculosis infection in India and much of the developing countries. The liver has a central role in drug metabolism, detoxification, and is consequently vulnerable to injury. Anti tubercular drugs induced liver injury can occur in all age groups including children with significant morbidity and mortality. Intolerance of anti-TB standard therapy, including INH, RIF and PZA is a serious problem in Tuberculosis patients. The clinical spectrum includes asymptomatic elevation in liver enzymes contributes to the liver failure. We report a rare case of Pyrazinamide induced hepatitis along with severe gastritis in a patient infected with newly diagnosed tubercular pericardial effusion and was treated symptomatically by changing the Antitubercular regimens.

Keywords: Tuberculosis, Drug Induced Liver Injury, Pyrazinamide, Gastritis, Hepatitis, Tubercular Pericardial Effusion.