Abstract

HOMOLOGY MODELING AND STRUCTURE PREDICTION FOR 40S RIBOSOMAL PROTEIN OF ENTAMOEBA HISTOLYTICA AND DOCKING STUDIES WITH CATECHIN

Jayashree K.P, Geetha Vishwanath, Guruprasad R*

ABSTRACT

The ribosome is a large and complex molecular machine, found within all living cells, A study was carried out to investigate the in-silico analysis of homology modeling and 3D structure prediction of 40s ribosomal protein from entamoeba histolytica. The models were validated using protein structure checking tools RAMPAGE, and molecular docking studies of the ligand catechin with 40s ribosomal protein was done by using software autodock and pymol. Docking studies provides most detailed possible view of drug receptor interaction and has created a new rational approach to drug design. Catechin bound with the structure predicted of above mentioned protein. These structures will provide a good foundation for functional analysis of experimentally derived crystal structures.

Keywords: Homology modeling, rampage validation and catechin.