Abstract

EFFECT OF BOLUS DOSE OF DEXMEDETOMIDINE ON HEMODYNAMIC RESPONSES AND AIRWAY REFLEXES DURING TRACHEAL EXTUBATION: DOUBLE BLIND, RANDOMIZED, CONTROLLED TRIAL STUDY

Shrirang Rao M.D.*, Somasekharam P M.D., Dinesh K M.D. and Ravi M M.D.

ABSTRACT

Background: To study the effect of bolus dose of dexmedetomidine on hemodynamic responses and airway reflexes during extubation. Methods: After obtaining institutional ethical committee approval and informed written consent 60 patients of ASA grade I and II in the age group of 18–50 years of either sex undergoing elective surgeries were included. At the closure of skin incision, patients received either dexmedetomidine 0.5 μg/kg (Group D) or saline (Group C) intravenously over 10 minutes. Hemodynamic parameters were assessed before, during and after extubation. Time to eye opening and extubation, side effects recorded. Extubation quality rated using 5-point scale. Sedation rated using Ramsay Sedation Scale. Results: Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were increased more in Group C. Time to extubation and eye opening were prolonged in Group D. Incidence of coughing & Agitation was more in Group C, hypotension was more in Group D. In dexmedetomidine group patients were more sedated post extubation. Extubation quality was better in dexmedetomidine group. Conclusions: We conclude that single- dose of dexmedetomidine 0.5 μg/kg body weight given over 10 minutes before extubation attenuates the hemodynamic and airway reflexes during emergence from anesthesia without causing undue sedation, but may prolong time to extubation and eye opening.

Keywords: Airway reflexes, Dexmedetomidine, Extubation, Hemodynamic responses.