Abstract

SOLUBILITY ENHANCEMENT OF CURCUMIN USING HPMC K 4M AND HPMC K 15M BY SOLVENT CHANGE PRECIPITATION METHOD

Pranali Waghmare, Dr. Pramod Kadu*

ABSTRACT

Objective: Curcumin naturally occurs from rhizomes of Curcuma longa L.; Zingiberaceae (Turmeric) is the most widely used phytoconstituent. It is highly Lipophilic, Insoluble in water at acidic or neutral pH. The major barrier to the clinical usefulness of Curcumin is its poor solubility and hence leads to poor Bioavailability. The aim of the present study is to increase the solubility of Curcumin. Method: Many methods are available to improve the solubility of Curcumin. Solid dispersion (SD) is one of the methods that involved a dispersion of one or more active ingredients in an inner carrier or matrix in solid state. For solid dispersion preparation, HPMC K 4M and HPMC K 15M is used as a hydrophilic carrier. It is prepared by combining the Curcumin and the polymers in a weight ratio of 1:1, 1:2, 1:3, and 1:4 by Solvent Change Precipitation Method. Result: It is found that the solid dispersion prepared using HPMC K 4M and HPMC K 15M increases the solubility of Curcumin. The increase in drug content was found only up to ratio 1:4 to the drug and polymer. In both the solid dispersion prepared using HPMC K 4M and HPMC K 15M. With the evidence of saturation solubility study, the solubility of solid dispersion increases in 0.1N HCl, Phosphate buffer pH 7.4 and distilled water, as the concentration of polymer increases. Conclusion: The solid dispersion prepared by solvent change precipitation method increases the solubility of Curcumin. HPMC K 15M and HPMC K 4M can be used as a potential hydrophilic carrier for the improvement of solubility of Curcumin which is the evidence of Drug content, Saturation solubility study, DSC and FTIR. And HPMC K 4M was found to be the superior hydrophilic carrier than HPMC K 15M to increase the solubility.

Keywords: Curcumin, Solid Dispersion, HPMC K 4M, HPMC K15M, Solvent change Precipitation.