Abstract

PATHOPHYSIOLOGY AND PHARMACOTHERAPY OF ATHEROSCLEROSIS

N. Ramya Krishna*, M. Sushma

ABSTRACT

Many recent studies have suggested that low-density lipoprotein (LDL) oxidation, endothelial dysfunction, and inflammation are involved in the pathogenesis of atherosclerosis Immune cells dominate early atherosclerotic lesions, their effect or molecules accelerate progression of the lesions, and activation of inflammation can elicit acute coronary syndromes. This review highlights the role of inflammation in the pathogenesis of atherosclerotic CAD. It will recount the evidence that atherosclerosis, the main cause of CAD, is an inflammatory disease in which immune mechanisms interact with metabolic risk factors to initiate, propagate, and activate lesions in the arterial tree. These facts force us to revisit cardiovascular disease and consider new strategies for prediction, prevention, and treatment.

Keywords: low-density lipoprotein, of atherosclerotic, treatment.