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Abstract

EVALUATION OF ANTIHYPERGLYCEMIC ACTIVITY OF LASIA SPINOSA LEAF EXTRACTS IN SWISS ALBINO MICE

Md. Nazmul Hasan, Mita Munshi, Mohammad Habibur Rahman, S.M. Nur Alam, Akinori Hirashima*

ABSTRACT

Lasia spinosa, locally known as Kohila is a stout, marshy plant with a creeping spiny rhizome. The tender leaves and rhizomes are used as vegetables and recommended for a variety of diseases in Ayurveda medicine. The present study was carried out to determine the anti-hyperglycemic effects of methanolic and ethanolic extracts of leaf of L. spinosa plant in oral glucose tolerance tests compared with standard (glibenclamide) in Swiss albino mice. Different extracts (methanolic and ethanolic) and dosses (200 and 400mg/kg bw-weight) for each extracts were orally administered. The serum blood glucose level was measured by glucometer after 2 h of gaveging of extracts and standard. Significant hypoglycemic activity was observed regarding both of the extracts and dosses compared to control. Both extracts revealed a significant (p<0.001) hypoglycemic activity and the methanolic extract showed the higher inhibitory activity than ethanolic extract. The results
of these experiments indicate that the leaf extract of L. spinosa shows potent anti-diabetic activity in mice model.

Keywords: Lasia spinosa, anti-hyperglycemic, methanolic extract, ethanolic extract, oral glucose tolerance test.


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