Abstract

FORMULATION AND EVALUATION OF ELETRIPTAN TRANSDERMAL PATCHES

Shyam P. Bihade*, Prof. R. G. Katedeshmukh, Dr. Madhur Kulkarni

ABSTRACT

The present work is focused on the development and evaluation of ELETRIPTAN transdermal patches. ELETRIPTAN is used as anti-migraine drug. Matrix types Transdermal Patches were prepared and the technique used is solvent evaporation technique. The transdermal patches were prepared using HPMC K100LV/ K15M grades polymers respectively. A total of 9 formulations were prepared with different quantities of HPMC polymers. These 9 formulations were divided into 3 sets. In 1stset HPMC K100LV polymer 2nd set HPMC K15M and 3rd set combination of HPMC K100LV & K15M. The solvent used for the preparation is water. PEG 400 was used as plasticizer. ELETRIPTAN drug is available in tablet form and its dose is twice a day i.e. 80mg/ day. The main work of this development of new technique is to overcome non compliance of tablet dosage form. This formulation is used for the patients who are suffering from acute migraine attack. The tablet form of drug should be administered twice a day i.e. 40mg at a time so to reduce continuous use of tablet this transdermal patch formulation would help to avoid continuous administration of tablet. The % drug release of the best batch i.e. optimized batch F1 was 86.43%. Transdermal patches of Eletriptan may provide sustained transdermal delivery for prolonged periods in the management of migraine, which can be a good way to bypass the extensive hepatic first-pass metabolism.

Keywords: HPMC, ELETRIPTAN, plasticizer.