Abstract

MICROSPHERES OF GLYCOPYRRONIUM BROMIDE FOR SUSTAINED DRUG DELIVERY

Manju Pal *, Dr. Amrita Bajaj, Dr. Pramod Kadu

ABSTRACT

Glycopyrronium Bromide an anti-muscarinic drug used in the treatment of asthma and COPD, was formulated as microspheres by using ethylcellulose as carrier polymer. The drug loaded ethyl cellulose microspheres were prepared by optimized spray drying technology. The prepared microspheres were subjected to physico-chemical evaluation and in-vitro release studies. High percentage drug entrapment was obtained with increasing drug polymer ratio. The particle sizes of the prepared microspheres were determined by Motic microscopy and SEM analysis. The prepared microspheres exhibited good spherical geometry with smooth surface as evidenced by SEM. The in-vitro release studies on Glycopyrronium Bromide microspheres of 1:3 ratios showed better sustained effect over a period of 12 hours. They were proved suitable for sustained oral delivery of the anti-muscarinic drug. The microspheres were also incorporated in Dry Powder Inhaler formulations for prolonged pulmonary delivery.

Keywords: Glycopyrronium Bromide, Ethyl cellulose, Microspheres.