Abstract

LIPOSPHERE REVIEW: METHODS AND ITS APPLICATIONS IN BIO-COMPATIBLE DRUG DELIVERY SYSTEM

Sandeep Vishnu Jadhav*, Dipika Punjaram Sadgir, Moreshwar Pandharinath Patil, Rohit Machindra Jagtap

ABSTRACT

Recently, advances in pharmaceutical research is focused on new delivery systems utilizing new devices to achieve modification of delivery time, targeting, as well as improve the in-vivo solubility and hence bioavailability of poorly soluble drugs. Lipospheres are new type of drug delivery system developed mainly for parenteral system. As most of the recent drugs discovered (nearly 40-45 %) are lipophilic in nature having poor water solubility and less bioavailability. Hence researchers are facing challenges in developing drug delivery system which is safe as well as effective. Lipospheres are made of solid hydrophobic triglycerides containing active moiety either dissolved (Lipophilic) or dispersed (Hydrophobic) & having a monolayer of phospholipids embedded on the surface of the particle. Lipospheres derived their name from lipid microspheres. These are generally used as carrier vehicle for hydrophobic drugs. However hydrophilic moieties such as Proteins & Peptides can be effectively delivered. Lipospheres are mainly composed of materials like triglycerides, waxes, oils etc. which avoids the toxicity than that bearing with the use of synthetic polymers concerns of monomers after intracellular processing of polymers and attractive benefits offered by lipids as carriers. This article reviews lipospheres in particular as delivery system. Lipid based drug delivery system (LDDS) or lipospheres are extensively employed as oral-delivery systems for drugs and other active ingredients in the field of pharmaceutical, food, agriculture & cosmetic technology.

Keywords: Lipid carrier, methods, recent advancements, solid lipid nanoparticles, biocompatible.