Abstract

WOUND HEALING ACTIVITY OF ROOT OF ZIZIPHUS JUJUBA MILL IN RAT MODEL

Manojkumar Z. Chopda*, Namrata V. Nemade And Raghunath T. Mahajan

ABSTRACT

The history of surgery in India and Ayurveda dates back. Sushruta, very succinctly described the reconstruction of the nose by cheek flap, skin grafting and classification of burns, wound care and wound healing. The magnitude of wound problem has stimulated research interests in the discovery and development of wound healing. Only few of the plant products are produced commercially by synthesis, for example, Curcumin derived from the Curcuma longa. Hence, efforts are made in the present investigation to isolate and to confirm the wound healing activity of Ziziphus jujuba. Partially purified product (ZjR) is amorphous in nature, light pale yellow in color, sparingly soluble in water and highly soluble in cholrofrom: methanol (80:20) and showed presence of reducing sugar and phenolic group. The yield of fraction of MeOHx of the root of Z.jujuba was found to be, ZjR -1.8% w/w. The ZjR exhibits significant wound healing activity (83.52%) on 8th day post wounding at a dose 0.5% as compared to control group of animals. Cultivation of this plant helps to improve economical health of farmers. This paper describes with use of root of Z. jujuba with possible mechanism of wound healing phenomenon.

Keywords: Wound healing, Ziziphus jujuba (Mill), Phenolic group.